Family and work are two things we really need to make priorities, but even with those we can work towards a healthy balance. With work whether self employed or not try to avoid "taking it home with you", be sure you make time for your family that doesn't involve work, maybe not take any work emails/phone calls after a certain time.
If you have kids, make sure that they, and you, aren't overloaded with two many activities or events, limit weekly activities to one sport or after school activity. And make them be creative and figure out how to entertain themselves and give you some stress free time. You both will benefit!
Little things like these may not seem like a big deal but can really make a difference in minimizing your stress and leading towards a more balanced life. Think of different ways you can find better balance and peace in your life.